To estimate a nationally representative baseline incidence, hospitalization data were extracted from the Discharge Abstract Database and was combined with data from Québec from the Ministère de la Santé et des Services sociaux. A national probable case definition and case report form were developed, and intentionally created to be highly sensitive to capture all potential cases for etiological investigations. Methods: A committee with representatives from PHAC and provincial/territorial health partners was established to investigate current cases in Canada. It further summarizes the outbreak investigation using information from the national case report forms. This article estimates the pre-existing baseline incidence of acute severe hepatitis of unknown origin in children in Canada using administrative databases. Clinical hepatitis, or inflammation of the liver, is not reportable in Canada, so to determine if an increase was occurring above historical levels, the baseline incidence in Canada was estimated. The Public Health Agency of Canada (PHAC) collaborated with provincial/territorial health partners to investigate in Canada. Keywords: acute severe hepatitis, unknown origin, children, outbreak investigation, administrative databases, baseline incidenceīackground: In spring 2022, a series of reports from the United Kingdom and the United States identified an increase in the incidence of acute severe hepatitis in children. Acute severe hepatitis of unknown origin in children in Canada. Macri J, Morton V, Hamel M, Trépanier P-L, Salvadori MI, Acute Hepatitis Investigation Team.

Jennifer Macri 1, Vanessa Morton 2, Meghan Hamel 3, Pierre-Luc Trépanier 4, Marina I Salvadori 5,6, Acute Hepatitis Investigation Team Affiliationsġ Canadian Field Epidemiology Program, Public Health Agency of Canada, Ottawa, ONĢ Centre for Food-borne, Environmental and Zoonotic Infectious Diseases, Public Health Agency of Canada, Guelph, ONģ Centre for Food-borne, Environmental and Zoonotic Infectious Diseases, Public Health Agency of Canada, Ottawa, ONĤ Ministère de la Santé et des Services sociaux, Montréal, QCĥ Public Health Agency of Canada, Ottawa, ONĦ Department of Paediatrics, McGill University, Montréal, Suggested citation Volume 49-6, June 2023: Acute Hepatitis in Children in Canada Surveillance Acute severe hepatitis of unknown origin in children in Canada

Unknown origins